Heralding a New Era of Episodic, Chronic and Refractory Migraine Management

Chaired by Paolo Martelletti
With Lars Edvinsson and Messoud Ashina

12th European Headache Federation Congress Springer Healthcare IME Symposium
Held on Friday 28th September, 2018, at Palazzo dei Congressi, Florence, Italy

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Includes presentation and video highlights from the expert faculty

At the end of the report try the quiz!

Watch Now: Faculty Interviews

   Welcome and introduction from Paolo Martelletti


Advances in the pathophysiology of migraine

    Lars Edvinsson  


New therapeutic options for episodic migraine

   Messoud Ashina 


Management of the chronic/refractory patient

  Paolo Martelletti



    14:00 Welcome and introduction
    Paolo Martelletti

    14:05 Advances in the pathophysiology of migraine
    Lars Edvinsson

    14:20 New therapeutic options for episodic migraine
    Messoud Ashina

    14:35 Management of the chronic/refractory patient
    Paolo Martelletti

    14:50 Faculty discussion and audience questions


    Following attendance at this symposium delegates are expected to:

    • Describe the advances in the pathophysiology and genetics of migraine as a chronic neurological condition
    • Discuss the emerging therapeutic options for patients with episodic and chronic migraine and their importance in reducing the burden of the condition of the patient
    • Deliberate how to identify patients with chronic refractory migraine and how to optimally manage these patients

    Dear Colleagues,

    Welcome to the cultural city of Florence and thank you for joining us at ‘Heralding a New Era of Episodic, Chronic and Refractory Migraine Management’, an independent symposium at the 12th European Headache Federation (EHF) Congress.

    The EHF is dedicated to increasing awareness of headache disorders and improving the quality of life of those affected by headache. The objective is to educate emerging doctors, neurologists, general practitioners and all those with an interest in headache management, and to support national headache societies in Europe.

    This symposium aims to cover the recent advances in the pathophysiology of migraine as well as discuss the new and emerging therapeutic options for patients with episodic, chronic and refractory migraine and their role in reducing the burden of this debilitating condition.

    Following the symposium we hope that your knowledge and understanding of this area will be enhanced and that you can utilise the learning in your daily practice. Our intention is to make the session as interactive as possible so you will have several chances to express your professional opinion as well as put questions to the expert Faculty.

    We would be grateful if you could provide your feedback by completing the
    evaluation form provided.

    Many thanks and enjoy the meeting!


    Prof Paolo Martelleti – Chair

  • Paolo Martelletti (Chair)

    Associate Professor and Chairman, Internal and Emergency Medicine, Sapienza University, Rome, Italy

    Read more about Martelletti

    Paolo Martelletti is associate professor and chairman of internal and emergency medicine in the Department of Clinical and Molecular Medicine at Sapienza University in Rome, Italy. He is the current president of the European Headache Federation (EHF), a post he has held since 2016, and editor-in-chief and founder of the Journal of Headache and Pain.

    Professor Martelletti is a worldwide expert clinician and has been a researcher in the field of headache disorders for four decades. His studies have primarily focused on the neuroimmunology of headache disorders, the multifaceted aspects of advances in therapeutics and, more recently, the application of personalised medicine to headache.

    Professor Martelletti is co-founder and past chairman of the World Health Organization (WHO) global campaign against headache, Lifting the Burden, and is European expert for the European Medicines Agency. Between 2014 and 2015 he was president of the Italian Society for the Study of Headache (SISC). He has been, and is currently, an editorial board member for multiple medical journals and has authored close to 200 indexed publications and contributed to over 200 book chapters on topics ranging from headache, rheumatology, pain and internal medicine.


    Prof Lars Edvinsson

    Professor of Internal Medicine, Lund University, Sweden

    Read more about Edvinsson

    Lars Edvinsson is professor of internal medicine at the Lund University in Sweden and a physician in the Department of Emergency and Internal Medicine at the Skåne University Hospital, Scania, Sweden. He is currently president of the International Headache Society, has co-authored over 950 scientific publications and is the author of Cerebral Blood Flow & Metabolism, a major textbook in this field.

    Professor Edvinsson is a leading expert in the field of cerebral circulation and migraine and has received global recognition for his work on vascular innervation and receptor regulation. His extensive research has been a major contributor to what is known about the roles of the cerebral vasculature in health and diseases such as stroke and primary headaches.

    His expertise include immunohistochemistry,  molecular biology of cell signaling, proteomics, animal models for acute stroke and acute myocardial infarcts, pharmacology and treatment methods, string and perfusion myography for receptor and functional studies of isolated blood vessels.


    Prof Messoud Ashina

    Professor of Neurology, Health and Medical Sciences, University of Copenhagen, Denmark

    Read more about Ashina

    Messoud Ashina is professor of neurology in the Faculty of Health and Medical Sciences, University of Copenhagen, and director of the Human Migraine Research Unit at the Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup in Copenhagen, Denmark.

    Professor Ashina has been actively involved in headache research since 1995. His research interests include experimental migraine and cluster headache models, functional neuroimaging, novel antimigraine drug targets, the mechanism of migraine and action of antimigraine medications. He has authored over 400 papers, abstracts and book chapters on the topic of headache, including migraine.


    The Heralding a new era of episodic, chronic and refractory migraine management, Florence, Italy, 28/09/2019-28/09/2019 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 1 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.

    Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international-activities.

    Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.


    This programme is made possible thanks to independent medical educational sponsorship from Eli Lilly and Company.